Recurrent Spontaneous Seizure State Induced by Prefrontal Kindling in Senegalese Baboons, Papio Papio

• DOI: 10.1017/s031716710002062x
• Publication Date: 2016-07-28T11:31:33Z
• Authors: J.A. Wada; T. Osawa; T. Mizoguchi
• Keywords: Male; 2. Zero hunger; Behavior, Animal; Light; Action Potentials; Differential Threshold; Electroencephalography; Amygdala; Functional Laterality; Frontal Lobe; 03 medical and health sciences; 0302 clinical medicine; Recurrence; Seizures; Animals; Female; Sleep Stages; Papio

SUMMARY: In our earlier study of amygdaloid kindling in Papio papio (Pp), the development partial complex seizure and focal motor was correlated with bifrontal theta discharge increasing Rolandic spike respectively final stage characterized by primary generalized convulsive seizure. Since latter pattern is known to originate from frontal focus man, cortex became suspect pattern. Daily prefrontal stimulation showed that Pp can be kindled this site, culminating a recurrent spontaneous state identical induced species. However, observation did not support original assumption regarding genesis Prefrontal are significantly different respect morphology, distribution propagation afterdischarge interictal discharge, speed clinical development. Most intriguingly, inter-ictal behavioral aberration associated depth EEG changes observed only animals animals.