Pharmacological Modification of Bradykinin Induced Breakdown of the Blood-brain Barrier

• DOI: 10.1017/s0317167100036301
• Publication Date: 2016-07-28T11:37:40Z
• Authors: Jennifer J. Raymond; David M. Robertson; Henry B. Dinsdale
• Keywords: Cerebral Cortex; Indomethacin; Imidazoles; Blood Pressure; Rats, Inbred Strains; Bradykinin; Trifluoperazine; Rats; Arterioles; Microscopy, Electron; 03 medical and health sciences; 0302 clinical medicine; Blood-Brain Barrier; Animals; Pinocytosis; Female; Horseradish Peroxidase

Internal carotid artery infusion of bradykinin caused extensive breakdown the blood-brain barrier to protein as demonstrated by extravasation marker, horseradish peroxidase, into vessel walls and adjacent parenchyma. Pretreatment animals with indomethacin, trifluoperazine, or imidazole significantly reduced quantity abnormally permeable vessels determined light microscopy. By electron microscopy, it was that an intense increase in number pinocytotic vesicles segments, but no change interendothelial junctions. After pretreatment, although extent permeability markedly reduced, intensity activity involved areas not altered.