Ambient PM2.5 exposure and tuberculosis reactivation: a cross-sectional study in an intermediate burden city

• DOI: 10.1017/s0950268824001808
• Publication Date: 2025-01-02T06:52:36Z
• Authors: Leonia Hiu Wan Lau; Ngai Sze Wong; Chi Chiu Leung; Chi Kuen Chan; Lai-bun Tai; Alexis Kai Hon Lau; Changqing Lin; Shui Shan Lee
• Keywords: Cross-sectional study

Hong Kong is an intermediate tuberculosis (TB) endemicity city dominated by reactivation diseases. A cross-sectional study on the clinical and epidemiologic data of newly diagnosed TB cases was conducted in such a setting, to examine association between ambient PM2.5 reactivation. After exclusion most likely resulting from recent infection, four distinct population phenotypes were delineated latent class analysis based their risk profiles (N = 2,153): 'Elderly male' (26%), 'Otherwise healthy younger adult' (34%), 'Older female' (19%) 'Male smoker' (21%). Overall, exposure high concentrations 6 12 months before notification significantly associated with adults' membership (OR 1.07 1.11, respectively) compared male'. Such less evident for other phenotypes. The differential pattern suggested role