Aurora kinase A is essential for correct chromosome segregation in mouse zygote

• DOI: 10.1017/s0967199415000222
• Publication Date: 2015-07-15T11:24:23Z
• Authors: Veronika Kovarikova; Jan Burkus; Pavol Rehak; Adela Brzakova; Petr Solc; Vladimir Baran
• Keywords: Aurora A kinase; Aurora B kinase; Multipolar spindles; Aurora kinase; Cleavage (geology)

Aurora-A kinase (AURKA), a member of the serine/threonine protein family, is involved in multiple steps mitotic progression. It regulates centrosome maturation, spindle formation, and cytokinesis. While studied extensively somatic cells, little information known about AURKA early cleavage mouse embryo with respect to acentrosomal assembly. In vitro experiments which was inactivated specific inhibitor MLN8237 during stages embryogenesis documented gradual arrest ability embryo. AURKA-inhibited 1-cell embryos, formation anaphase onset were delayed chromosome segregation defective. inhibition increased apoptosis embryonic development. conclusion these data suggest that essential for correct first mitosis as prerequisite normal later development after cleavage.