Thalamic atrophy and cognition in unilateral temporal lobe epilepsy

• DOI: 10.1017/s1355617708080399
• Publication Date: 2008-04-17T17:02:22Z
• Authors: MICHAEL SEIDENBERG; BRUCE HERMANN; DALIN PULSIPHER; JARED MORTON; JOY PARRISH; ELIZABETH GEARY; LESLIE GUIDOTTI
• Keywords: Abnormality

This study examined quantitative magnetic resonance volumes of the thalamus and hippocampus determined their relationship with cognitive function clinical seizure characteristics in a sample 46 unilateral temporal lobe epilepsy (TLE) subjects (20 left 26 right) 29 controls. The exhibited different patterns volume abnormality, associations characteristics, measures. Hippocampal reduction was primarily ipsilateral to focus, thalamic bilateral. Ipsilateral hippocampal significantly correlated both early neurodevelopmental features (age onset) disease (duration epilepsy), whereas integrity related only variables. showed selective association verbal memory performance. In contrast, right were performance on nonmemory domains. These findings underscore importance atrophy chronic TLE its potential implications for cognition. (JINS, 2008, 14, 384–393.)