The heterogeneity of mild cognitive impairment: A neuropsychological analysis

• DOI: 10.1017/s1355617709990993
• Publication Date: 2009-11-03T13:44:56Z
• Authors: DAVID J. LIBON; SHARON X. XIE; JOEL EPPIG; GRAHAM WICAS; MELISSA LAMAR; CAROL LIPPA; BRIANNE M. BETTCHER; CATHERINE C. PRICE; TANIA GIOVANNETTI; ROD SWENSON; DENENE M. WAMBACH
• Keywords: Dysexecutive syndrome; Neuropsychological Assessment; Memory Impairment

Abstract A group of 94 nondemented patients self-referred to an outpatient memory clinic for difficulties were studied determine the incidence single versus multi-domain mild cognitive impairment (MCI) using Petersen criteria. Fifty-five community dwelling normal controls (NC) participants without complaints also recruited. Tests assessing executive control, naming/lexical retrieval, and declarative administered. Thirty-four exhibited single-domain MCI, 43 presented with MCI. When entire MCI sample ( n = 77) was subjected a cluster analysis, 14 classified amnesic 21 dysexecutive 42 into mixed/multi-domain involving low scores on tests letter fluency, “animal” delayed recognition discriminability. Analyses comparing three cluster-derived groups NC confirmed presence groups. The mixed produced lower fluency compared naming group. In summary, is quite common. These data suggest that highly nuanced complex clinical entity. JINS , 2010, 16 84–93.)