Perceived Fatigue Impact and Cognitive Variability in Multiple Sclerosis

• DOI: 10.1017/s1355617721000230
• Publication Date: 2021-03-31T05:14:24Z
• Authors: Kaitlin E. Riegler; Margaret Cadden; Erin T. Guty; Jared M. Bruce; Peter A. Arnett
• Keywords: Neuropsychological test

Abstract Objective: People with Multiple Sclerosis (PwMS) and healthy controls (HCs) were evaluated on cognitive variability indices we examined the relationship between fatigue these groups. Intraindividual (IIV) a neuropsychological test battery was hypothesized to mediate group differences expected in fatigue. Method: Fifty-nine PwMS 51 HCs completed psychosocial interview of tests questionnaires during 1-day visit. Fatigue this study measured Impact Scale (FIS), self-report multidimensional measure IIV operationalized using two different measures, maximum discrepancy score (MDS) intraindividual standard deviation (ISD), domains, memory attention/processing speed. Two mediation analyses (PwMS or HCs) as independent variable, composite (memory speed) measures mediators, total residual (after accounting for age) outcome, depression covariate conducted. The Baron Kenny approach testing PROCESS macro strength indirect effect used. Results: Results analysis 5000 bootstrap samples indicated that domains both speed significantly mediated patient status Conclusion: is an objective performance related impact HCs. experience more across variable may increase