CryoTEM as an Advanced Analytical Tool for Materials Chemists

• DOI: 10.1021/acs.accounts.7b00107
• Publication Date: 2017-06-30T19:09:12Z
• Authors: Joseph P. Patterson; Yifei Xu; Mohammad-Amin Moradi; Nico A. J. M. Som...; Heiner Friedrich
• Keywords: Microscale chemistry

ConspectusMorphology plays an essential role in chemistry through the segregation of atoms and/or molecules into different phases, delineated by interfaces. This is a general process materials synthesis and exploited many fields including colloid chemistry, heterogeneous catalysis, functional molecular systems. To rationally design complex materials, we must understand control morphology evolution. Toward this goal, utilize cryogenic transmission electron microscopy (cryoTEM), which can track structural evolution solution with nanometer spatial resolution temporal <1 s.In Account, review examples our own research where direct observations cryoTEM have been to understanding macromolecular self-assembly, inorganic nucleation growth, cooperative hybrid materials. These three areas are at heart approach take inspiration from myriad Nature. Biological formed using limited number chemical components under ambient conditions, their formation pathways were refined during biological enormous trial error approaches self-organization biomineralization. By combining information on what possible nature focusing components, aim provide insight structure synthesis. Bone, for example, hierarchical material lightweight, yet strong hard. It self-assembly collagen template nano- microscale structure. then directs growth oriented, nanoscale calcium phosphate crystals form composite material. Fundamental controlling these structuring processes will eventually allow us such predetermined potentially unique properties.