Combined Endothelialization Promoting and Surface Binding Chimeric Conjugate with Low Thrombogenicity

• DOI: 10.1021/acs.bioconjchem.1c00152
• Publication Date: 2021-06-30T18:49:46Z
• Authors: Matthias Gabriel; Avneesh Chopra; Franziska Schmidt
• Keywords: Thrombogenicity; Silanization; Conjugate; Surface Modification

Endothelialization of blood contacting implants, e.g., vascular stents, is regarded as a prerequisite for an improved performance in terms minimizing thrombogenicity and the inhibition restenosis. Commonly used materials, such Ti-based alloys, can be surface-modified order to improve endothelial cell (EC) colonization well reduce platelet adhesion. Standard modification techniques involve silanization are laborious time-consuming. We propose novel single-step procedure based on surface-recognizing peptide generated by phage display methodology. Combining this with polyethylene glycol (PEG) spacer EC-specific sequence yielded conjugate applicable Ti surfaces.