Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing

• DOI: 10.1021/acs.biomac.3c01385
• Publication Date: 2024-03-19T20:19:27Z
• Authors: Ming Yan; Shi-Yu Hu; Zhi-Guo Wang; Rui Hong; Xu Peng; Maja Kuzmanović; Min Yang; Rui Dai; Yanqiong Wang; Juxiang Gou; Ka Li; Jia-Zhuang Xu; Zhong-Ming Li
• Keywords: Biocompatibility

The treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties strong applicability are urgently needed. Herein, we developed a composite by constructing multiple networks loading ciprofloxacin for wound healing. was synthesized via Schiff base reaction between carboxymethyl chitosan oxidized sodium alginate, followed polymerization acrylamide monomer. resultant dressing possessed good self-healing ability, considerable compression strength, reliable fatigue resistance. In vitro assessment showed that effectively eliminated bacteria exhibited an excellent biocompatibility. model