Codelivery of Doxorubicin and p53 Gene by β-Cyclodextrin-Based Supramolecular Nanoparticles Formed via Host–Guest Complexation and Electrostatic Interaction

• DOI: 10.1021/acs.biomac.4c00123
• Publication Date: 2024-04-08T15:55:18Z
• Authors: Ying Jie Ooi; Yuting Wen; Jingling Zhu; Xia Song; Jun Li
• Keywords: Cationic polymerization

We developed a supramolecular system for codelivery of doxorubicin (Dox) and p53 gene based on β-CD-containing star-shaped cationic polymer. First, polymer consisting β-CD core 3 arms oligoethylenimine (OEI), named CD-OEI, was used to form inclusion complex with hydrophobic Dox. The CD-OEI/Dox subsequently condense plasmid DNA via electrostatic interactions CD-OEI/Dox/DNA polyplex nanoparticles positive surface charges that enhanced the cellular uptake both Dox DNA. This drug showed high transfection efficiency effective protein expression in cancer cells. encoding resulted reduced cell viability antitumor effects at low concentrations. With its anticancer efficacy, holds promise as delivery carrier potential combination therapies.