Peptidic Monodisperse PEG “combs” with Fine-Tunable LCST and Multiple Imaging Modalities

• DOI: 10.1021/acs.biomac.8b01693
• Publication Date: 2019-01-24T09:27:02Z
• Authors: Junfei Zhu; Yan Xiao; Huaibin Zhang; Yu Li; Yaping Yuan; Zhigang Yang; Shizhen Chen; Xing Zheng; Xin Zhou; Zhong-Xing Jiang
• Keywords: Dispersity; Biocompatibility; Biological Imaging

Thermosensitive and imaging-traceable materials with fine-tunable lower critical solution temperature (LCST) around body are highly valuable in biomedicine. However, such rare because it is challenging to fine-tune the LCST incorporate suitable imaging modalities. Herein, peptidic monodisperse polyethylene glycol (M-PEG) "combs" LCST, "hot spot" fluorine-19 magnetic resonance (19F MRI), thermoresponsive fluorescent imaging, drug loading ability were developed through accurately programming their structures during solid phase peptide synthesis (SPPS). The easy availability, structural accuracy, biocompatibility, versatility provide M-PEG promising prospects as biomaterials for controlled delivery.