Cocrystal or Salt Crystallization for Active Pharmaceutical Ingredients By Using Deep Eutectic Solvents

• DOI: 10.1021/acs.cgd.3c00155
• Publication Date: 2023-08-18T11:53:22Z
• Authors: Masataka Ito; Yuriko Iwata; Hiroyasu Iwasaki; Kyu Hayashi; Taku Nakayama; Hidemasa Hikawa; Isao Azumaya; Hironori Suzuki; Shuji Noguchi
• Keywords: Cocrystal; Environmentally Friendly

Active pharmaceutical ingredients (APIs) often exhibit physicochemical problems that one can remedy by various methods (e.g., salt formation, grinding, ordered mixtures, and cocrystal or amorphous formation). Crystallizing salts cocrystals from solutions of an API a coformer is widely used today. In recent years, green chemistry sustainable development goals have been active area research, production method required for reducing the use organic solvents implementing low environmental load. this study, deep eutectic (DESs) were as mother liquids crystallization environmentally friendly solvents. The DESs made combining three types choline compound malonic acid. Nine model APIs then dissolved in each DES crystals precipitated DESs. As result, five kinds 10 conditions, two which identified first time study. Crystallization using potent alternative discovering novel with impact.