Influence of Fluid Motions on Polymorphic Crystallization of l-Histidine: Taylor Vortex Flow and Turbulent Eddy Flow

• DOI: 10.1021/acs.cgd.7b01067
• Publication Date: 2017-12-22T20:45:02Z
• Authors: Suna Park; Woo-Sik Kim
• Keywords: 02 engineering and technology; 0210 nano-technology

The mechanistic influence of fluid motions, such as a Taylor vortex flow and turbulent eddy flow, on the polymorphic crystallization l-histidine was investigated. Couette–Taylor (CT) mixing tank (MT) crystallizers were used for respectively. Due to its periodic motion, found be more favorable than nucleation stable phase. Thus, fraction phase at induction point (called "initial fraction") in CT crystallizer always much higher that MT all variations conditions, including rotation/agitation speed, ethanol mixture solvent, cooling rate. When increasing rotation speed inner cylinder crystallizer, initial significantly increased reached 100% above 700 rpm. A not achievable even high agitation over 2500 also effective mass transfer. transformation rate several scores crystallizer. with two motions when varying described using simple model based flow-induced successfully predicted experimental results both conditions. According model, motion promoting transformation.