Improving Compliance and Decreasing Drug Accumulation of Diethylstilbestrol through Cocrystallization

• DOI: 10.1021/acs.cgd.8b01911
• Publication Date: 2019-01-24T20:07:22Z
• Authors: Zhen Li; Meiqi Li; Bo Peng; Bingqing Zhu; Jian-rong Wang; Xuefeng Mei
• Keywords: 02 engineering and technology; 0210 nano-technology; 3. Good health

Diethylstilbestrol (DES), a synthetic nonsteroidal estrogen, has been prescribed for advanced breast cancer and prostate cancer. However, its poor compliance, reactive metabolite toxicity and hydro...