Comparing Effects of Redox Sensitivity of Organic Nanoparticles to Photodynamic Activity

• DOI: 10.1021/acs.chemmater.7b00207
• Publication Date: 2017-02-01T20:14:14Z
• Authors: Wei Zhang; Wenhai Lin; Xiaohua Zheng; Shasha He; Zhigang Xie
• Keywords: Diselenide; Diphenyl diselenide; Nanomaterials; Rose bengal

Smart responsive nanomaterials, which are sensitive to biological signals, promising therapeutic formulations. It has been well studied that redox potential is much different at both tissue and cellular level. In this work, three organic nanoparticles with variable sensitivity were fabricated, their was evaluated compared in detail. First, diselenide, disulfide, carbon–carbon bond containing porphyrin dimers TPP-SeSe/TPP-SS/TPP-CC synthesized. Then, the corresponding self-assembled (TPP-SeSe/TPP-SS/TPP-CC NPs) prepared via nanoprecipitation method. As-synthesized utilized systematically compare stimuli responsiveness reductive agents (e.g., glutathione) conditions, especially living cells, through singlet oxygen generation ability cytotoxicity. A series of experimental results demonstrated diselenide shows better superiority reduction than disulfide or bond, contributed faster delivery photosensitizer facilitated exertion PDT activity. These highlight be developed as a novel effective platform fabricate more functional stimuli-responsive nanomaterials.