Chemical and Toxicological Characterization of Vaping Emission Products from Commonly Used Vape Juice Diluents

• DOI: 10.1021/acs.chemrestox.0c00174
• Publication Date: 2020-07-03T09:38:24Z
• Authors: Huanhuan Jiang; C. M. Sabbir Ahmed; Thomas J. Martin; Alexa Canchola; Iain W. H. Oswald; Jose Andres Garcia; Jin Y. Chen; Kevin A. Koby; Anthony J. Buchanan; Zixu Zhao; Haofei Zhang; Kunpeng Chen; Ying-Hsuan Lin
• Keywords: Diluent

Recent reports have linked severe lung injuries and deaths to the use of e-cigarettes vaping products. Nevertheless, causal relationship between exposure emissions observed health outcomes remains be elucidated. Through chemical toxicological characterization emission products, this study demonstrates that during processes, changes in composition several commonly used vape juice diluents (also known as cutting agents) lead formation toxic byproducts, including quinones, carbonyls, esters, alkyl alcohols. The resulting condensates cause inhibited cell proliferation enhanced cytotoxicity human airway epithelial cells. Notably, substantial duroquinone durohydroquinone redox couple was from vitamin E acetate, which may acute oxidative stress reported by previous studies. These findings provide an improved molecular understanding highlight significant role byproducts vaping-associated effects.