PFOS-Induced Perturbations in Trophoblast Functions through the Oip5os1/miR-155/Rnd3 Axis in PE

• DOI: 10.1021/acs.chemrestox.4c00184
• Publication Date: 2025-01-14T12:13:47Z
• Authors: Xiaomin Ye; Peiqu Zhong; Qiongfang Chen; Dongmei Zhou; Jieyu Luo; Youcai Liang; Jiayuan Zhang; Lijian Zhao
• Keywords: Trophoblast

The widespread use of perfluorooctanesulfonic acid (PFOS) has raised concerns regarding its potential on pregnant women, particularly in relation to the development pre-eclampsia (PE). This study investigates impact PFOS exposure LncRNA/Rnd3 axis mice and association with trophoblast cell functions PE. Bioinformatics analysis revealed PFOS-related gene alterations PE, pathways enriched apoptotic signaling cytokine interactions. Experimental findings showed downregulation Oip5os1 Rnd3, along upregulation miR-155, affecting behavior. Animal experiments confirmed that PFOS-induced expression changes are linked PE progression. impairs proliferation migration via Oip5os1/miR-155/Rnd3 axis, contributing development.