A History of the Molecular Initiating Event

0301 basic medicine 0303 health sciences 03 medical and health sciences Animals Humans Toxicology Risk Assessment 3. Good health
DOI: 10.1021/acs.chemrestox.6b00341 Publication Date: 2016-11-17T00:11:47Z
ABSTRACT
The adverse outcome pathway (AOP) framework provides an alternative to traditional $\textit{in vivo}$ experiments for the risk assessment of chemicals. AOPs consist of a number of key events (KEs) linked by key event relationships across a range of biological organization backed by scientific evidence. The first KE in the pathway is the molecular initiating event (MIE)-the initial chemical trigger that starts an AOP. Over the past 3 years the AOP conceptual framework has gained a large amount of momentum in toxicology as an alternative to animal methods, and so the MIE has come into the spotlight. What is an MIE? How can MIEs be measured or predicted? What research is currently contributing to our understanding of MIEs? In this Perspective we outline answers to these key questions.
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