A History of the Molecular Initiating Event

• DOI: 10.1021/acs.chemrestox.6b00341
• Publication Date: 2016-11-17T00:11:47Z
• Authors: Timothy E. H. Allen; Jonathan M. Goodman; Steve Gutsell; Paul J. Russell
• Keywords: 0303 health sciences; 03 medical and health sciences; Animals; Humans; Toxicology; Risk Assessment

The adverse outcome pathway (AOP) framework provides an alternative to traditional in vivo experiments for the risk assessment of chemicals. AOPs consist a number key events (KEs) linked by event relationships across range biological organization backed scientific evidence. first KE is molecular initiating (MIE)-the initial chemical trigger that starts AOP. Over past 3 years AOP conceptual has gained large amount momentum toxicology as animal methods, and so MIE come into spotlight. What MIE? How can MIEs be measured or predicted? research currently contributing our understanding MIEs? In this Perspective we outline answers these questions.