Urinary Metabolites of Neonicotinoid Insecticides: Levels and Recommendations for Future Biomonitoring Studies in China

• DOI: 10.1021/acs.est.0c01227
• Publication Date: 2020-05-11T08:46:37Z
• Authors: Shiming Song; Tao Zhang; Yingyan Huang; Bo Zhang; Yuankai Guo; Yuan He; Xiongfei Huang; Xueyuan Bai; Kurunthachalam Ka...
• Keywords: Neonicotinoid; Acetamiprid

Neonicotinoids (NEOs) are insecticides that widely used around the world. Following exposure, NEOs get metabolized in human bodies. The biomarkers to assess NEO exposure not well described because of lack information on metabolites (m-NEOs). In this study, five m-NEOs including N-desmethyl-acetamiprid (N-dm-ACE), 5-hydroxy-imidacloprid (5-OH-IMI), olefin-imidacloprid (Of-IMI), 1-methyl-3-(tetrahydro-3-furylmethyl) guanidine (DIN-G), and (DIN-U) were measured 275 urine samples collected from 10 cities China. All frequently detected with median concentrations ranging 0.42 (DIN-G) 1.02 (5-OH-IMI) ng/mL. urinary N-dm-ACE 5-OH-IMI China higher than those reported Japan USA. comparison parent (i.e., acetamiprid, ACE; imidacloprid, IMI; dinotefuran, DIN) same set by our research group, ratios m-NEO corresponding (m-NEO/NEO) ranged 4.95 (DIN-G/DIN) 37.7 (N-dm-ACE/ACE), indicating mainly present as rather forms. Furthermore, ratio Σm-NEOs/ΣNEOs was significantly (p < 0.01) females males, suggesting more readily or highly exposed m-NEOs. To knowledge, is first study measure Of-IMI, DIN-G, DIN-U levels We recommend biomonitoring studies include N-dm-ACE, 5-OH-IMI, (and DIN-G) for clear understanding ACE, IMI, DIN, respectively.