Microplastics Aggravate the Bioaccumulation of Two Waterborne Veterinary Antibiotics in an Edible Bivalve Species: Potential Mechanisms and Implications for Human Health

• DOI: 10.1021/acs.est.0c01575
• Publication Date: 2020-06-12T22:01:29Z
• Authors: Weishang Zhou; Yu Han; Yu Tang; Wei Shi; Xueying Du; Shuge Sun; Guangxu Liu
• Keywords: Florfenicol; Detoxification

Edible bivalves are one of the major types seafood and may be subject to antibiotic microplastics (MPs) coexposure under realistic scenarios. However, effect MPs on bioaccumulation antibiotics in edible subsequent health risks for consumers remain poorly understood. Therefore, two frequently detected veterinary antibiotics, oxytetracycline (OTC) florfenicol (FLO), with or without copresence was investigated blood clam. Health associated consumption contaminated clams were also assessed. Furthermore, activity GST expression key detoxification genes analyzed as well. The OTC FLO found aggravated by MPs. Because estimated target hazard quotients (THQs) far less than critical value, direct toxic effects consuming negligible. dietary exposure doses human gut microbiota (DEGM) tested greater similar corresponding minimum selective concentrations (MSC), indicating a potential resistance risk. Moreover, significantly suppressed MPs, suggesting that disruption represents possible explanation observed here.