Development of an Enhanced Mechanistically Driven Mode of Action Classification Scheme for Adverse Effects on Environmental Species

• DOI: 10.1021/acs.est.0c06551
• Publication Date: 2021-01-22T07:08:40Z
• Authors: Maria Sapounidou; David J. Ebbrell; Mark A. Bonnell; Bruno Campos; James W. Firman; Steve Gutsell; Geoff Hodges; Jayne Roberts; Mark T. D. Cronin
• Keywords: Mode of Action; Mode (computer interface)

This study developed a novel classification scheme to assign chemicals verifiable mechanism of (eco-)toxicological action allow for grouping, read-across, and in silico model generation. The new unifies extends existing schemes has, at its heart, direct reference molecular initiating events (MIEs) promoting adverse outcomes. is based on three broad domains toxic representing nonspecific toxicity (e.g., narcosis), reactive mechanisms electrophilicity free radical action), specific associated with enzyme inhibition). organized further levels detail beyond separate out the mechanistic group, mechanism, MIEs responsible. novelty this approach comes from taxonomic diversity within classification, transparency, quality supporting evidence relating MIEs, that it can be updated readily.