Associations of Prenatal Exposure to Per- and Polyfluoroalkyl Substances with the Neonatal Birth Size and Hormones in the Growth Hormone/Insulin-Like Growth Factor Axis

• DOI: 10.1021/acs.est.1c02670
• Publication Date: 2021-08-11T14:59:43Z
• Authors: Dan Luo; Weixiang Wu; Yanan Pan; Bibai Du; Mingjie Shen; Lixi Zeng
• Keywords: Perfluorooctane; Perfluorooctanoic acid

Toxicological data suggest a significant developmental toxicity of per- and polyfluoroalkyl substances (PFASs); however, evidence in humans remains inconclusive. Furthermore, the effects prenatal exposure to PFASs on hormones growth hormone (GH)/insulin-like factor (IGF) axis newborns remain largely unclear. We aimed investigate associations with neonatal birth size, GH, IGF-1, IGF-binding protein 3 (IGFBP-3). The concentrations 22 were measured plasma 224 pregnant women collected within days before delivery (39.3 weeks) Guangzhou, China, anthropometric gathered from medical records. Paired cord blood was at determine IGFBP-3 levels. Multivariable linear regression models revealed inverse several long-chain weight ponderal index as well perfluorobutanoic acid perfluorooctanoic (PFOA) Bayesian kernel machine confirmed association perfluorooctane sulfonate PFOA identified an joint effect mixture multiple weight. findings provide first comprehensive individual size GH/IGF axis, which requires further confirmation.