Ambient Air Pollutants and Traffic Factors Were Associated with Blood and Urine Biomarkers and Asthma Risk

• DOI: 10.1021/acs.est.1c06916
• Publication Date: 2022-03-03T22:00:30Z
• Authors: Haoxiang Cheng; Antonio Di Narzo; Daniel Howell; Kateryna Yevdokimova; Jushan Zhang; Xingmin Zhang; Qi Pan; Zhongyang Zhang; Linda Rogers; Ke Hao
• Keywords: Air Pollutants; 0303 health sciences; Nitrogen Dioxide; Environmental Exposure; Asthma; 3. Good health; 03 medical and health sciences; 13. Climate action; Air Pollution; 11. Sustainability; Humans; Environmental Pollutants; Particulate Matter; Biomarkers

The UK Biobank (UKBB) is a large population-based cohort that provides unique opportunity to study the association between environmental exposure and biomarkers identify as potential instruments for assessing dose, health damage, disease risks. On 462 063 participants of European ancestry, we characterized relationship 38 disease-relevant biomarkers, asthma diagnosis, ambient pollution, traffic factors, genetic background. air pollutant on UKBB was fairly low (e.g., mean PM2.5 concentration at 10.0 μg/m3). Nevertheless, 30 were in with least one factor; e.g., C-reactive protein levels positively associated NO (padj = 2.99 × 10–4), NO2 4.15 1.92 10–6) even after multiple testing adjustment. Asthma diagnosis four pollutants (NO, NO2, PM2.5, PM10). largest effect size observed where 5 μg/m3 increment 1.52 increase (p 4.41 10–13). Further, predisposition influenced biomarker an additive model. exposure–biomarker associations identified this could serve indicators induced damages. Our results also shed light possible mechanisms whereby influences disease-causing turn increases risk.