Short-Term Exposure of PM2.5 and Epigenetic Aging: A Quasi-Experimental Study

Adult 0301 basic medicine Aging 0303 health sciences Superoxide Dismutase Environmental Exposure DNA Methylation 01 natural sciences Epigenesis, Genetic 03 medical and health sciences Air Pollution Humans Particulate Matter Biomarkers 0105 earth and related environmental sciences
DOI: 10.1021/acs.est.2c05534 Publication Date: 2022-10-05T12:27:49Z
ABSTRACT
Epigenetic age (EA) is an emerging DNA methylation-based biomarker of biological aging, but whether EA causally associated with short-term PM2.5 exposure remains unknown. We conducted a quasi-experimental study 26 healthy adults to test accelerates seven EAs three health examinations performed before, during, and after multiple pollution waves. Seven were derived from the methylation profiles Illumina HumanMethylationEPIC BeadChip CD4+ T-helper cells. found that increase 10 μg/m3 in 0–24 h personal prior was 0.035, 0.050, 0.055, 0.052, 0.037-unit changes z-scored acceleration (AA,Horvath), AA (Hannum), (GrimAge), DunedinPoAm, mortality risk score (MS), epiTOC, respectively (p-values < 0.05). The same 24–48 average yielded smaller effects still robustly MS. Such acute aging mediated by several circulating biomarkers, including EC-SOD sCD40L, up ∼28% proportions. Our findings demonstrated could accelerate reflected via blood coagulation, oxidative stress, systematic inflammation.
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