Short-Term Exposure of PM2.5 and Epigenetic Aging: A Quasi-Experimental Study

• DOI: 10.1021/acs.est.2c05534
• Publication Date: 2022-10-05T12:27:49Z
• Authors: Xu Gao; Jing Huang; Andres Cardenas; Yan Zhao; Yanyan Sun; Jiawei Wang; Lijun Xue; Andrea A. Baccarelli; Xinbiao Guo; Ling Zhang; Shaowei Wu
• Keywords: Adult; 0301 basic medicine; Aging; 0303 health sciences; Superoxide Dismutase; Environmental Exposure; DNA Methylation; 01 natural sciences; Epigenesis, Genetic; 03 medical and health sciences; Air Pollution; Humans; Particulate Matter; Biomarkers; 0105 earth and related environmental sciences

Epigenetic age (EA) is an emerging DNA methylation-based biomarker of biological aging, but whether EA causally associated with short-term PM2.5 exposure remains unknown. We conducted a quasi-experimental study 26 healthy adults to test accelerates seven EAs three health examinations performed before, during, and after multiple pollution waves. Seven were derived from the methylation profiles Illumina HumanMethylationEPIC BeadChip CD4+ T-helper cells. found that increase 10 μg/m3 in 0–24 h personal prior was 0.035, 0.050, 0.055, 0.052, 0.037-unit changes z-scored acceleration (AA,Horvath), AA (Hannum), (GrimAge), DunedinPoAm, mortality risk score (MS), epiTOC, respectively (p-values < 0.05). The same 24–48 average yielded smaller effects still robustly MS. Such acute aging mediated by several circulating biomarkers, including EC-SOD sCD40L, up ∼28% proportions. Our findings demonstrated could accelerate reflected via blood coagulation, oxidative stress, systematic inflammation.