Short-Term Exposure of PM2.5 and Epigenetic Aging: A Quasi-Experimental Study
Adult
0301 basic medicine
Aging
0303 health sciences
Superoxide Dismutase
Environmental Exposure
DNA Methylation
01 natural sciences
Epigenesis, Genetic
03 medical and health sciences
Air Pollution
Humans
Particulate Matter
Biomarkers
0105 earth and related environmental sciences
DOI:
10.1021/acs.est.2c05534
Publication Date:
2022-10-05T12:27:49Z
AUTHORS (11)
ABSTRACT
Epigenetic age (EA) is an emerging DNA methylation-based biomarker of biological aging, but whether EA causally associated with short-term PM2.5 exposure remains unknown. We conducted a quasi-experimental study 26 healthy adults to test accelerates seven EAs three health examinations performed before, during, and after multiple pollution waves. Seven were derived from the methylation profiles Illumina HumanMethylationEPIC BeadChip CD4+ T-helper cells. found that increase 10 μg/m3 in 0–24 h personal prior was 0.035, 0.050, 0.055, 0.052, 0.037-unit changes z-scored acceleration (AA,Horvath), AA (Hannum), (GrimAge), DunedinPoAm, mortality risk score (MS), epiTOC, respectively (p-values < 0.05). The same 24–48 average yielded smaller effects still robustly MS. Such acute aging mediated by several circulating biomarkers, including EC-SOD sCD40L, up ∼28% proportions. Our findings demonstrated could accelerate reflected via blood coagulation, oxidative stress, systematic inflammation.
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