Prenatal Exposure to Legacy and Alternative Per- and Polyfluoroalkyl Substances and Neuropsychological Development Trajectories over the First 3 Years of Life

• DOI: 10.1021/acs.est.2c07807
• Publication Date: 2023-02-17T21:00:31Z
• Authors: Qing-Qing Li; Jinbo Huang; Dan Cai; Wei-Chun Chou; Mohammed Zeeshan; Chu Chu; Yang Zhou; Lizi Lin; Hui-Min Ma; Cuilan Tang; Minli Kong; Yanqi Xie; Guang-Hui Dong; Xiao-Wen Zeng
• Keywords: Odds

The neurotoxic effects of prenatal exposure to per- and polyfluoroalkyl substances (PFAS) on offspring animals are well-documented. However, epidemiological evidence for legacy PFAS is inconclusive, alternative PFAS, it little known. In this investigation, we selected 718 mother–child pairs from the Chinese Maoming Birth Cohort Study measured 17 in third-trimester serum. Neuropsychological developments (communication, gross motor function, fine problem solving ability, personal–social skills) were assessed at 3, 6, 12, 18, 24, 36 months using Ages Stages Questionnaires 3rd edition. Trajectories each subscale classified into persistently low high groups via group-based trajectory modeling. Logistic regression grouped weighted quantile sum fitted assess potential individual their mixtures, respectively. Higher linear PFHxS levels associated with elevated odds trajectories communication (OR = 1.73; 95% CI: 1.12, 2.66) ability 2.11; 1.14, 3.90). Similar findings observed PFOS, 1m-PFOS, PFDA, PFDoDA, PFUnDA, mixture. no association was We provided insights longitudinal links between legacy/alternative neuropsychological development over first 3 years life.