Multi- and Transgenerational Developmental Impairments Are Induced by Decabromodiphenyl Ethane (DBDPE) in Zebrafish Larvae

• DOI: 10.1021/acs.est.3c00032
• Publication Date: 2023-02-13T10:44:40Z
• Authors: Yumiao Sun; Shanqi Zhou; Biran Zhu; Fan Li; Kaiyu Fu; Yongyong Guo; Jun Men; Jian Han; Wei Zhang; Lihua Yang; Bingsheng Zhou
• Keywords: Transgenerational epigenetics; Environmental toxicology; Decabromodiphenyl ether; Brominated flame retardant; Aquatic toxicology; Neurotoxicity

A novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant; hence, the knowledge of its long-term toxic effects and underlying mechanism would be critical for further health risk assessment. In present study, multi- transgenerational toxicity DBDPE was investigated in zebrafish upon life cycle exposure at environmentally relevant concentrations. The significantly increased malformation rate declined survival specifically occurred unexposed F2 larvae suggested development by DBDPE. changing profiles revealed transcriptome DNA methylome confirmed an susceptibility figured out potential disruptions glycolipid metabolism, mitochondrial energy neurodevelopment. changes biochemical indicators such as ATP production disturbance whereas alterations neurotransmitter contents light–dark stimulated behavior provided evidence neurotoxicity zebrafish. Our findings also highlighted necessity considering impacts when evaluating wild animals well human beings pollutants.