Arginine Metabolism Reprogramming in Perfluorooctanoic Acid (PFOA)-Induced Liver Injury

• DOI: 10.1021/acs.est.4c07971
• Publication Date: 2025-01-10T18:36:57Z
• Authors: Jie Gao; Tiantian Li; Wei Guo; Meilin Yan; Junran Liu; Xiaolong Yao; Meilin Lv; Yun Ding; Hua Qin; Minghao Wang; Runzeng Liu; Jun Liu; Chunzhen Shi; Jianbo Shi; Guangbo Qu; Guibin Jiang
• Keywords: Perfluorooctanoic acid; Metabolic pathway

Perfluorooctanoic acid (PFOA) is a persistent pollutant that has gained worldwide attention, owing to its widespread presence in the environment. Previous studies have reported PFOA upregulates lipid metabolism and associated with liver injury humans. However, when fatty degradation pathway activated, accumulation still occurs, suggesting of unknown pathways mechanisms remain be elucidated. In this study, adult C57BL/6N mice were exposed at 0.1, 1, 10 mg/kg/day. Using integrated metabolomics transcriptomics, it was uncovered arginine differentially downregulated all three groups. vitro confirmed downregulation MIHA cell lines treated PFOA. Supplementation could effectively rescue downregulate chemokine levels caused by This finding highlights contribution maintaining health following exposure suggests potential metabolic immune modulation.