Arginine Metabolism Reprogramming in Perfluorooctanoic Acid (PFOA)-Induced Liver Injury
Perfluorooctanoic acid
Metabolic pathway
DOI:
10.1021/acs.est.4c07971
Publication Date:
2025-01-10T18:36:57Z
AUTHORS (16)
ABSTRACT
Perfluorooctanoic acid (PFOA) is a persistent pollutant that has gained worldwide attention, owing to its widespread presence in the environment. Previous studies have reported PFOA upregulates lipid metabolism and associated with liver injury humans. However, when fatty degradation pathway activated, accumulation still occurs, suggesting of unknown pathways mechanisms remain be elucidated. In this study, adult C57BL/6N mice were exposed at 0.1, 1, 10 mg/kg/day. Using integrated metabolomics transcriptomics, it was uncovered arginine differentially downregulated all three groups. vitro confirmed downregulation MIHA cell lines treated PFOA. Supplementation could effectively rescue downregulate chemokine levels caused by This finding highlights contribution maintaining health following exposure suggests potential metabolic immune modulation.
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