Fine Particulate Matter Constituents, Nitric Oxide Synthase DNA Methylation and Exhaled Nitric Oxide

• DOI: 10.1021/acs.est.5b02527
• Publication Date: 2015-09-15T18:14:57Z
• Authors: Renjie Chen; Liping Qiao; Huichu Li; Yan Zhao; Yunhui Zhang; Wenxi Xu; Cuicui Wang; Hongli Wang; Zhuohui Zhao; Xiaohui Xu; Hui Hu; Haidong Kan
• Keywords: Exhaled breath condensate; Exhalation

It remains unknown how fine particulate matter (PM2.5) constituents affect differently the fractional concentration of exhaled nitric oxide (FeNO, a biomarker airway inflammation) and DNA methylation its encoding gene (NOS2A). We aimed to investigate short-term effects PM2.5 on NOS2A FeNO. designed longitudinal study among chronic obstructive pulmonary disease (COPD) patients with six repeated health measurements in Shanghai, China. applied linear mixed-effect models evaluate associations. observed that inverse association between at position 1 was limited within 24 h, positive FeNO strongest lag day. Organic carbon, element NO3(-) NH4(+) were robustly significantly associated decreased elevated An interquartile range increase total four decreases 1.19, 1.63, 1.62, 1.17, 1.14 percent NOS2A, respectively, increases 13.30%,16.93%, 8.97%, 18.26%, 11.42% FeNO, respectively. Our results indicated organic might be mainly responsible for COPD patients.