Conceptual Framework To Extend Life Cycle Assessment Using Near-Field Human Exposure Modeling and High-Throughput Tools for Chemicals

• DOI: 10.1021/acs.est.6b02277
• Publication Date: 2016-09-26T22:10:50Z
• Authors: Susan A. Csiszar; David E. Meyer; Kathie L. Dionisio; Peter Egeghy; Kristin K. Isaacs; Paul S. Price; Kelly A. Scanlon; Yu-Mei Tan; Kent Thomas; Daniel Vallero; Jane C. Bare
• Keywords: Conceptual framework; Prioritization; Exposure Assessment; Conceptual model

Life Cycle Assessment (LCA) is a decision-making tool that accounts for multiple impacts across the life cycle of product or service. This paper presents conceptual framework to integrate human health impact assessment with risk screening approaches extend LCA include near-field chemical sources (e.g., those originating from consumer products and building materials) have traditionally been excluded LCA. A new generation rapid exposure modeling high-throughput toxicity testing transforming prioritization provides an opportunity integration screening-level (RA) The combined RA approach considers environmental alongside risks health, which consistent regulatory frameworks addressing within sustainability mindset. case study presented juxtapose used in product. demonstrates how these tools can be inform estimates highlights needs future research. basis developing methods support decision making on use chemicals products.