Environmental Microcystin Exposure Increases Liver Injury Risk Induced by Hepatitis B Virus Combined with Aflatoxin: A Cross-Sectional Study in Southwest China

• DOI: 10.1021/acs.est.6b05404
• Publication Date: 2017-05-03T14:52:55Z
• Authors: Wenyi Liu; Lingqiao Wang; Xiaohong Yang; Hui Zeng; Renping Zhang; Chaowen Pu; Chuanfen Zheng; Yao Tan; Yang Luo; Xiaobin Feng; Yingqiao Tian; Guosheng Xiao; Jia Wang; Yujing Huang; Jiaohua Luo; Lei Feng; Feng Wang; Changyou Yuan; Yuan Yao; Zhiqun Qiu; Ji-an Chen; Liping Wu; Qingqing Nong; Hui Lin; Weiqun Shu
• Keywords: Cross-sectional study

Three liver hazards, two confirmed-hepatitis B virus (HBV) and aflatoxin (AFB), one rarely studied in populations-microcystin (MC), simultaneously exist tropical humid areas; however, there are no epidemiological data on their risks the same population. We conducted a community-based cross-sectional survey among 5493 adults rural towns statistically analyzed comparative combinative effects of three factors after detecting HBsAg HBV DNA titers, determining estimated daily intakes (EDIs) AFB1 MC-LR testing serum AST ALT as injury markers for each participant. observed HBsAg(+) rate 7.6%, relatively high exposure level (mean EDIAFB1 = 471.30 ng/d), low EDIMC-LR 228.25 ng/d). ORs abnormal (2.42, 95%CI 1.69-3.45) (2.87, 1.91-4.29) increased infections compared with HBV-unexposed participants but did not increase separate or combined to (EDIs ≥ mean). Meanwhile, adjustment confounding factors, means were successively elevated HBV, HBV&AFB1 (or HBV&MC-LR), HBV&AFB1&MC-LR, especially group detectable (AST: OR 11.38, 3.91-33.17; ALT: 17.09, 5.36-54.53). Notably, exposed significantly different from those HBV&MC-LR higher HBV&AFB1&MC-LR (P 0.029 P 0.037, respectively). Our study indicated that microcystin may have potential risk induced by aflatoxin. However, consideration uncertainties detection toxins evaluation EDIs, more expected determine increasing toxic microcystins.