Bisphenol A Metabolites and Bisphenol S in Paired Maternal and Cord Serum

• DOI: 10.1021/acs.est.6b05718
• Publication Date: 2017-01-22T16:24:21Z
• Authors: Jiaying Liu; Jingguang Li; Yongning Wu; Yunfeng Zhao; Fengji Luo; Shuming Li; Lin Yang; Elham K. Moez; Irina Dinu; Jonathan W. Martin
• Keywords: Benzhydryl compounds; Glucuronide; Cord blood

Human studies show associations between maternal bisphenol A (BPA) exposure and developmental effects in children, yet biomonitoring of BPA metabolites fetal serum remains limited, less is known for alternatives. BPA-glucuronide, BPA-sulfate, S (BPS) were quantified 61 pairs cord sera from Chinese participants. Total BPS was only detectable four (<0.03–0.07 ng/mL) seven (<0.03–0.12 ng/mL), indicating low but providing the first evidence that crosses human placenta. significantly higher than (p < 0.05), suggesting these may be formed fetus or cleared more slowly fetoplacental compartment. Unlike pharmacokinetic results controlled oral which BPA-glucuronide major metabolite, here, BPA-sulfate dominant metabolite (GM: 0.06 0.08 0.02 0.04 0.01) both sera. Moreover, proportion increased with total BPA. These are data paired serum, suggest pregnant mother have unique to metabolites. Direct analysis provides complementary information evaluating early life-stage risks