Arsenic Relative Bioavailability in Rice Using a Mouse Arsenic Urinary Excretion Bioassay and Its Application to Assess Human Health Risk

• DOI: 10.1021/acs.est.7b00495
• Publication Date: 2017-03-16T09:09:15Z
• Authors: Hong-Bo Li; Jie Li; Di Zhao; Chao Li; Xue-Jiao Wang; Hong-Jie Sun; Albert L. Juhasz; Lena Q. Ma
• Keywords: 2. Zero hunger; mice; arsenic; 0211 other engineering and technologies; Biological Availability; health; Food Contamination; Oryza; 02 engineering and technology; 01 natural sciences; Arsenic; 3. Good health; animals; biological availability; Mice; food contamination; Health; Animals; Humans; Biological Assay; 0105 earth and related environmental sciences

A steady-state mouse model was developed to determine arsenic (As) relative bioavailability (RBA) in rice refine As exposure humans. Fifty-five samples from 15 provinces of China were analyzed for total As, with 11 cooked speciation and assessment. Arsenic concentrations 38-335 μg kg-1, averaging 133 AsIII being dominant (36-79%), followed by DMAV (18-58%) AsV (0.5-16%). Following oral doses individual species mice at low (2.5-15 per mouse) over a 7-d period, strong linear correlations (R2 = 0.99) observed between urinary excretion cumulative intake, suggesting the suitability sensitivity bioassay measure As-RBA rice. Urinary factor (0.46) less than inorganic (0.63-0.69). ranged 13.2 ± 2.2% 53.6 11.1% (averaging 27.0 12.2%) 26.2 7.0% 49.5 4.7% 39.9 8.3%) As. Calculation intake based on overestimated 2.0-3.7 fold compared that bioavailable For accurate assessment health risk associated consumption, it is important consider especially