Exposure to Crude Oil Induces Retinal Apoptosis and Impairs Visual Function in Fish

• DOI: 10.1021/acs.est.9b07658
• Publication Date: 2020-02-10T05:21:35Z
• Authors: Jason T. Magnuson; Naim M. Bautista; JoAnn Lucero; Amie K. Lund; Elvis Genbo Xu; Daniel Schlenk; Warren W. Burggren; Aaron P. Roberts
• Keywords: Cardiotoxicity; Danio; Optokinetic reflex

Polycyclic aromatic hydrocarbons (PAHs) present in crude oil are known to impair visual development fish. However, the underlying mechanism of PAH-induced toxicity system fish is not understood. Embryonic zebrafish (Danio rerio) at 4 h post fertilization were exposed weathered and assessed for function using an optokinetic response, with subsequent samples taken immunohistochemistry gene expression analysis. Cardiotoxicity was also by measuring heart rate, stroke volume, cardiac output, as performance has been proposed be a contributing factor eye-associated malformations following exposure. Larvae highest concentrations (89.8 μg/L) exhibited increased occurrence bradycardia, though no changes volume or output observed. genes important eye phototransduction downregulated oil-exposed larvae, cellular apoptosis, reduced neuronal connection, behavioral response larvae.