Platinum(II)-Metallaclip-Based Theranostics for Cell Imaging and Synergetic Chemotherapy–Photodynamic Therapy

• DOI: 10.1021/acs.inorgchem.2c01206
• Publication Date: 2022-06-29T17:11:48Z
• Authors: Yang Wang; Ruowen Tang; Di Wang; Jian Wang; Yuying Huang; Yue Ding; Bing Lu; Yan Sun; Peter J. Stang; Yong Yao
• Keywords: Tetraphenylethylene; Proton NMR

Supramolecular coordination complexes formed by coordination-induced assembly not only avoid the loss of activity precursors but also provide an efficient way for controlled release, which can be further used in various fields biology such as drug delivery, cell imaging, and tumor treatment. In this work, a PtII metallaclip (4) was prepared from 4-[4-(1,2,2-triphenylvinyl)phenyl]pyridine (1), 5,10,15-triphenyl-20-(pyridin-4-yl)porphyrin (2), 90o Pt, glycol-chain-modified isophthalic acid (3) acetone/water mixture through "coordination-driven self-assembly" method. 31P 1H NMR spectroscopy high-resolution mass spectrometry were to characterize obtained 4. 4 self-assemble into fluorescent nanostructures aqueous solution because tetraphenylethylene unit its amphiphilic nature. Importantly, nanoparticles employed imaging generate singlet oxygen (1O2) under 660 nm laser irradiation release Pt issue cancer therapy. The work may new scientists construct functional biomaterials with multiple applications via molecular self-assembly.