Inhibitory Effects of Bound Polyphenol from Foxtail Millet Bran on Colitis-Associated Carcinogenesis by the Restoration of Gut Microbiota in a Mice Model

• DOI: 10.1021/acs.jafc.0c00370
• Publication Date: 2020-02-26T13:51:07Z
• Authors: Ruipeng Yang; Shuhua Shan; Chen Zhang; Jiangying Shi; Hanqing Li; Zhuoyu Li
• Keywords: Foxtail

Colorectal cancer (CRC) is a common malignant tumor occurring in the colon. It has been known that gut microbiota complex ecosystem and plays an important role pathogenesis of colorectal cancer. Our previous study showed bound polyphenol inner shell (BPIS) from foxtail millet bran exhibited significant antitumor activities cells nude mice models. In present study, anticancer potential BPIS evaluated azoxymethane (AOM) dextran sodium sulfate (DSS)-induced mouse CRC model. Results could decrease number volume tumors protect epithelial architecture damage. Certain biomarkers associated with formation, such as COX-2, EMR1, PCNA, caspase-3, were strongly changed by BPIS. Moreover, 16S rRNA gene sequence analysis, it was found remodel overall structure tumor-bearing toward normal counterparts, including two phyla eight genera, together regulations on several genes are responsible for 17 signaling pathways.