Sargassum fusiforme Fucoidan Alleviates High-Fat Diet-Induced Obesity and Insulin Resistance Associated with the Improvement of Hepatic Oxidative Stress and Gut Microbiota Profile

• DOI: 10.1021/acs.jafc.0c02555
• Publication Date: 2020-08-31T17:20:14Z
• Authors: Ya Zhang; Jihui Zuo; Liping Yan; Yang Cheng; Qiaojuan Li; Siya Wu; Ling Chen; Ronald W. Thring; Yue Yang; Yitian Gao; Mingjiang Wu; Haibin Tong
• Keywords: Fucoidan

Sargassum fusiforme fucoidan (SFF) exhibits diverse biological activities. Insulin resistance (IR) implicated in type 2 diabetes (T2D) has become an epidemic health issue worldwide. In this study, we investigated whether SFF can improve insulin sensitivity high-fat diet (HFD)-fed mice. Our present data showed that significantly reduced fasting blood glucose and IR index along with improved tolerance. Impaired phosphorylation of Akt was also restored by SFF. Furthermore, decreased the levels MDA 4-HNE-modified protein increased GSH/GSSG ratio as well elevated antioxidant enzymes activated Nrf2 signaling. abundance diversity gut microbiota obese mice, intestinal integrity inflammation. findings suggested ameliorated HFD-induced through activating pathway, remodeling microbiota, reducing inflammation, thus providing a novel perspective into treatment strategy on metabolic disease.