Serum Metabonomic Study on the Antidepressant-like Effects of Ellagic Acid in a Chronic Unpredictable Mild Stress-Induced Mouse Model

• DOI: 10.1021/acs.jafc.0c02895
• Publication Date: 2020-08-06T00:47:13Z
• Authors: Xiaoxia Huang; Wu Li; Bangyan You; Wanpei Tang; Tingsheng Gan; Chao Feng; Congfa Li; Ruili Yang
• Keywords: Ellagic Acid; Tail suspension test

As a polyphenol, ellagic acid (EA) has shown potential antidepressant activity. In this study, the effects and serum metabolomic analysis of EA against depression were investigated using chronic unpredictable mild stress-induced (CUMS) model. (20 or 100 mg/kg body weight) significantly ameliorated CUMS-induced depression-like behaviors, including reduced weight, decreased sucrose preference, increased immobility time in both tail suspension test forced swimming test. Furthermore, attenuated hippocampal damage brain-derived neurotrophic factor (BDNF) serotonin (5-HT) levels as well suppressed inflammatory response. The metabolomics showed that disturbance glycerophospholipid (phosphatidylethanolamine phosphatidylinositol), amino (l-arginine N-stearoyl serine), purine (uric acid) metabolism induced by CUMS was treatment. correlation indicated metabolite changes strongly correlated with behavioral disorders, BDNF, 5-HT, cytokines levels. This study provided new insights for suggests may be nutraceutical improving management depression.