Chrysin Inhibits Melanoma Tumor Metastasis via Interfering with the FOXM1/β-Catenin Signaling

• DOI: 10.1021/acs.jafc.0c03123
• Publication Date: 2020-08-15T02:18:14Z
• Authors: Zheng Yufei; Wu Yuqi; Hu Binyue; Tao Lingchen; Chen Xi; Dixon Hoffelt; Hu Fuliang
• Keywords: Chrysin; FOXM1

Melanoma, which features high metastasis and lethality, is one of the toughest tumors to treat. Chrysin, rich in various plants, has shown a great inhibitory effect on melanoma proliferation. Here, we evaluated suppressive chrysin vivo vitro. In vitro, effectively inhibited ankios resistance from 5 μM cell migration, invasion 10 μM, tube formation capacity cells 20 μM. We discovered that interfered with mesenchymal–epithelial transition via regulating FOXM1/β-catenin signaling, as expression key regulatory factors was downregulated by treatment, overexpression FOXM1 will attenuate antimetastasis chrysin. also tested lung colonization metastasis, where found fewer were formed lungs chrysin-treated mice. addition, vivo. Collectively, our findings suggested ability treatment lower metastatic rate through indicating application potential for therapy.