Effects of Casein, Chicken, and Pork Proteins on the Regulation of Body Fat and Blood Inflammatory Factors and Metabolite Patterns Are Largely Dependent on the Protein Level and Less Attributable to the Protein Source

• DOI: 10.1021/acs.jafc.0c03337
• Publication Date: 2020-08-15T02:48:12Z
• Authors: Shangxin Song; Tianlan Xia; Changqing Zhu; Jingqi Xue; Qingquan Fu; Chun Hua; Guido J. E. J. Ho...; Michael Müller; Chunbao Li
• Keywords: Male; 0301 basic medicine; 2. Zero hunger; obesity; Swine; Meat Proteins; Caseins; 612; Interleukin-10; Rats; rats; untargeted metabolomics; 03 medical and health sciences; high-fat diet; Adipose Tissue; meat protein; Pork Meat; Animals; Cattle; Obesity; Rats, Wistar; Chickens

The impact of meat protein on metabolic regulation is still disputed and may be influenced by level. This study aimed to explore the effects casein, pork, chicken proteins at different levels (40% E vs 20% E) body weight regulation, fat accumulation, serum hormone levels, inflammatory factors/metabolites in rats maintained high-fat (45% fat) diets for 84 d. Increased resulted a significant reduction mass an increase anti-inflammatory cytokine IL-10, independent source. Analysis blood via untargeted metabolomics analysis identified eight, four, four metabolites significantly altered level, source, level–source interaction, respectively. Together, chicken, pork accumulation metabolite profile are largely dependent level less attributable