Maternal Fucosyltransferase 2 Status Associates with the Profiles of Human Milk Oligosaccharides and the Fecal Microbiota Composition of Breastfed Infants

• DOI: 10.1021/acs.jafc.0c04575
• Publication Date: 2021-03-06T13:28:27Z
• Authors: Fan Liu; Jingyu Yan; Xifan Wang; Chenyuan Wang; Lingli Chen; Yiran Li; Jianliang Chen; Huiyuan Guo
• Keywords: Bifidobacterium longum

Human milk oligosaccharides (HMOs) play key roles in shaping infant fecal microbiota, and HMOs profiles have been reported to vary according the mother's glycosyltransferase phenotype. In this study, of human from secretor or non-secretor mothers collected at 2 months postpartum were analyzed by liquid chromatography quadrupole time-of-flight tandem mass spectrometry. 16S rRNA sequencing was used characterize microbiota breastfed infants. The amount total fucosylated higher than mothers, while Bifidobacterium genus highly enriched infants fed mothers. Associations between showed that relative abundance Bifidobacterium-OTU158 positively associated with 2'-fucosyllactose 3-fucosyllactose, Bifidobacterium-OTU90 negatively lacto-N-difucohexaose. present study provides HMO Chinese their associations composition, suggesting compositions are different strains species-specific manner.