Impact of Antibiotic-Induced Depletion of Gut Microbiota and Selenium Supplementation on Plasma Selenoproteome and Metal Homeostasis in a Mice Model

• DOI: 10.1021/acs.jafc.1c02622
• Publication Date: 2021-06-25T22:09:07Z
• Authors: Belén Callejón-Le...; Marta Selma-Royo; María Carmen Collado; Nieves Abril; Tamara García-Bar...
• Keywords: Homeostasis; Dysbiosis

Selenium (Se) is a micronutrient involved in important health functions and it has been suggested to shape gut microbiota. Limited information on Se assimilation by microbes the possible link with selenoproteins are available. For this purpose, conventional microbiota-depleted BALB/c mice were fed Se-supplemented diet. The absolute quantification of plasma was performed for first time using heteroatom-tagged proteomics. microbiota profile analyzed 16S rRNA gene sequencing. Se-supplementation modulated concentration antioxidant glutathione peroxidase Se-transporter selenoalbumin as well metal homeostasis, being influenced disruption, which suggests an intertwined mechanism. also diversity richness increased relative abundance some health-relevant taxa (e.g., families Christensenellaceae, Ruminococcaceae, Lactobacillus genus). This study demonstrated potential beneficial effects microbiota, especially after antibiotic-treatment associations between specific bacteria selenoproteins.