Sulforaphane Regulates Glucose and Lipid Metabolisms in Obese Mice by Restraining JNK and Activating Insulin and FGF21 Signal Pathways

Sulforaphane FGF21 Carbohydrate Metabolism Cruciferous vegetables
DOI: 10.1021/acs.jafc.1c04933 Publication Date: 2021-10-28T05:13:30Z
ABSTRACT
The most common complications of obesity are metabolic disorders such as nonalcoholic fatty liver disease (NAFLD), hyperglycemia, and low-grade inflammation. Sulforaphane (SFN) is a hydrolysate glucosinolate (GLS) that found in large quantities cruciferous vegetables. objective this research was to evaluate the mechanism by which SFN relieves obese mice. C57BL/6J mice were fed high-fat diet induce treated daily with 10 mg/(kg body weight (bw)) for 8 weeks, while positive control group 300 bw) metformin. Our results indicated attenuated NAFLD, inflammation, oxidative stress, adipose tissue hypertrophy, insulin resistance, well regulated glucose lipid metabolism. metabolism deactivating c-Jun N-terminal kinase (JNK) blocking inhibitory effect signaling pathway. also alleviating fibroblast growth factor 21 (FGF21) resistance. provides an empirical basis clinical treatment obesity.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (48)
CITATIONS (27)