Pterostilbene Coupled with Physical Exercise Effectively Mitigates Collagen-Induced Articular Synovial by Correcting the PI3K/Akt/NF-κB Signal Pathway

• DOI: 10.1021/acs.jafc.1c05819
• Publication Date: 2021-11-09T18:55:17Z
• Authors: Guliang Yang; Jie Sun; Kun Lu; Sijie Shan; Shiming Li; Chenglin Sun
• Keywords: Pterostilbene

Studies have revealed that a novel anti-inflammatory mediator─maresin-1 (MaR1)─can reduce the level of inflammatory factors. There is evidence physical exercise (PE) promotes biosynthesis MaR1, leading to prevention rheumatoid arthritis (RA). Previously, we proven resveratrol can mitigate formation RA. Pterostilbene (Pte) an analogue resveratrol, but it around four times more bioavailable. Hence, hypothesize Pte could be effective in preventing RA, particular, when accompanied by moderate PE. Based on this hypothesis, explored preventive effect combined with PE bovine type II collagen (BIIC)-stimulated rat RA model and its underlying molecular mechanism. Compared BIIC-stimulated group, serum content MaR1 continuous intervention plus for 8 weeks was significantly increased 46.3 pg/mL from 7.2 BIIC-treated alone. Besides, variation relative expression levels p-NF-κB p-Akt reversed administration More importantly, vitro results confirmed treatment inhibited proliferation apoptosis promoted autophagy interleukin (IL)-1β-stimulated primary synovial cells through PI3K/Akt/NF-κB signal pathway. Collectively, oral helped ameliorate pathological process correcting