Photoprotective Mechanism of Fucoxanthin in Ultraviolet B Irradiation-Induced Retinal Müller Cells Based on Lipidomics Analysis

• DOI: 10.1021/acs.jafc.1c07980
• Publication Date: 2022-02-24T12:43:31Z
• Authors: Yixin Shi; Jiaying Ren; Baomin Zhao; Taihai Zhu; Hang Qi
• Keywords: Photoprotection

Long-term exposure to sunlight and/or blue light causes vision damage people of all ages. Dietary pigments and polyphenols have been shown photoprotective potential for eyes; however, many unknowns regarding the protective mechanism remain. In this study, we used ultraviolet B (UVB) irradiation-induced retinal Müller cells (RMCs) screen dietary pigment compounds with effective activity. Fucoxanthin (FX) was best therapeutic effect, evaluated via lipidomics analysis. Both intra- extracellular ROS, mitochondrial depolarization, DNA induced by UVB irradiation were inhibited FX. Meanwhile, FX modulated MAPK signaling pathway, which is correlated apoptosis inflammation. Our data revealed that regulated lipid metabolism disorder protected membrane structure. These results confirm effects FX, may lead new insights into FX-functionalized foods.