Neohesperidin Dihydrochalcone Ameliorates High-Fat Diet-Induced Glycolipid Metabolism Disorder in Rats

• DOI: 10.1021/acs.jafc.2c03574
• Publication Date: 2022-07-21T18:26:55Z
• Authors: Yecheng Xiao; Donglin Su; Xing Hu; Guliang Yang; Yang Shan
• Keywords: Mice, Inbred C57BL; Mice; 0303 health sciences; 03 medical and health sciences; Chalcones; Metabolic Diseases; Hesperidin; Animals; Glycolipids; Diet, High-Fat; Rats; 3. Good health

High-fat diet (HFD) is closely related to the formation of metabolic diseases. Studies have confirmed that neohesperidin dihydrochalcone (NHDC) possesses biological activity preventing glycolipid metabolism disorder. To explore mechanism its preventive against glucolipid disorder, HFD-treated rats were orally administered with NHDC for 12 weeks continuously. The results showed that, compared HFD group, intervention 40-80 mg/kg body weight effectively downregulated level fasting blood glucose. Western blot analysis revealed treatment alleviated inhibitory effect on expression hepatic GLUT-4 and IRS-1. Further studies reduced degree HFD-stimulated inflammation ileum through TLR4/MyD88/NF-κB signaling pathway. Moreover, intestinal flora intragastric administration reversed change Proteobacteria abundance Firmicutes/Bacteroidetes (F/B) ratio caused by HFD. At generic level, promoted relative Coprococcus, Bifidobacterium, Clostridium, Oscillospira, [Eubacterium], while reducing Defluviitalea Prevotella. Taken together, these findings suggest improving HFD-induced