Dietary Turmeric Consumption Alleviates Ulcerative Colitis via Restoring Tryptophan Metabolism and Alleviating Gut Microbiota Dysbiosis in Mice

• DOI: 10.1021/acs.jafc.2c04509
• Publication Date: 2022-11-22T21:42:06Z
• Authors: Chengcheng Yang; Yao Du; Aiqing Zhao; Lei Liu; Daoyuan Ren; Pengfei Niu; Xiangnan Zhang; Yu Wang; Yan Zhao; Xingbin Yang
• Keywords: Dysbiosis

This study was designed to first verify the protective capacity of turmeric powder (TP) as a traditional cooking spice against dextran sulfate sodium (DSS)-induced intestinal inflammation and intestine microbiota imbalance. The DSS-induced mice were fed standard rodent chow supplemented with or without TP (8%) for 37 days. results indicated that pathological phenotype, gut barrier disruption, colon significantly improved through supplementation TP. In addition, 16S rRNA-based targeted metabolomics analysis ameliorated dysbiosis caused by DSS particularly enhanced abundances probiotics correlated tryptophan metabolism, such Lactobacillus Bifidobacterium, where cecal metabolized indole-3-propionic acid indole-3-acetic acid. Consumption markedly expression levels colonic aromatic hydrocarbon receptors further increased expressions tight junction proteins interleukin-22 in colitis mice. Collectively, these findings manifest actions dietary consumption ulcerative via restoring disorders, promoting microbial improving damage.