Molecular Responses and Degradation Mechanisms of the Herbicide Diuron in Rice Crops

• DOI: 10.1021/acs.jafc.2c05142
• Publication Date: 2022-11-03T15:22:41Z
• Authors: Xiao Dong Wang; Chen Yi Zhang; Yi Yuan; Yi Fei Hua; Tadao Asami; Yi Qin; Xiao Hui Xiong; Jian Liang Zhu; Yi Chen Lu
• Keywords: Detoxification; Xenobiotic; Biotransformation; Metabolic pathway

Diuron [DU; 3-(3,4-dichlorophenyl)-1,1-dimethylurea], a widely used herbicide for weed control, arouses ecological and health risks due to its environment persistence. Our findings revealed that DU at 0.125-2.0 mg L-1 caused oxidative damage rice. RNA-sequencing profiles disclosed globally genetic expression landscape of rice under treatment. mediated downregulated gene encoding photosynthesis biosynthesis protein, fatty acid, carbohydrate. Conversely, it induced the upregulation numerous genes involved in xenobiotic metabolism, detoxification, anti-oxidation. Furthermore, 15 metabolites produced by metabolic were identified, 7 which include two Phase I-based 5 II-based derivatives, reported first time. The changes resistance-related phytohormones, like JA, ABA, SA, terms their contents molecular-regulated signaling pathways positively responded stress. work provides molecular-scale perspective on response toxicity clarifies biotransformation degradation fate crops.