Alleviating Effect of Lacticaseibacillus rhamnosus 1.0320 Combined with Dihydromyricetin on Acute Alcohol Exposure-Induced Hepatic Impairment: Based on Short-Chain Fatty Acids and Adenosine 5′-Monophosphate-Activated Protein Kinase-Mediated Lipid Metabolism Signaling Pathway

• DOI: 10.1021/acs.jafc.2c08523
• Publication Date: 2023-03-17T21:24:21Z
• Authors: Wan Wang; Xu Zhao; Yue Ma; Jing Zhang; Cong Xu; Jiage Ma; Muhammad Altaf Hu...; Juncai Hou; Shanshan Qian
• Keywords: Steatosis

Excessive drinking has been listed by the World Health Organization as fifth major risk factor; especially liver, core organ of alcohol metabolism, is prone to organic lesions. Probiotics have received attention due their bioactivity for liver protection. The beneficial effects probiotics on hosts are related physiological functions. Therefore, based concept second-generation synbiotes, this study explored protective four dietary polyphenols stress tolerance, hydrophobicity, adhesion, and digestive characteristics L. rhamnosus 1.0320. 1.0320 had best synergistic effect with dihydromyricetin (DMY). combination was selected a synbiotic supplement explore acute exposure-induced hepatic impairment. results showed that combined DMY restored intestinal barrier upregulating short-chain fatty acid levels activated adenosine 5′-monophosphate-activated protein kinase-mediated lipid metabolism pathway inhibit oxidative stress, inflammation, accumulation in liver. Furthermore, 109 CFU/mouse/d 50 mg/kg/d gavage were identified optimal doses protection against expose-induced This provides new insights into alleviating alcoholic impairment targeting metabolites through gut-liver axis.