Gut Microbiota from Short-Chain Chlorinated Paraffin-Exposed Mice Promotes Astrocyte Activation by Disrupting the Intestinal Tight Junction via Zonulin Upregulation

• DOI: 10.1021/acs.jafc.3c01058
• Publication Date: 2023-05-19T11:06:08Z
• Authors: Xinyuan Zhao; Tao Zhang; Yudan Zheng; Zixuan Zhao; Wenjie Ding; Ziyang Zhang; Zeyao Zhang; Rui Wang; Man Jiao; Lei Liu; Shali Yu; Xiaoke Wang; Rongrong Huang; Qiyun Wu
• Keywords: Neurotoxicity; Intestinal Permeability; Gut–brain axis

Short-chain chlorinated paraffins (SCCPs) are novel toxicants in food and reported to possess neurotoxicity. Here, we investigated the mechanism of SCCP-induced astrocyte activation neuroinflammation. SCCP gavage induced neuronal cell death with changes gut microbiome metabolites. Antibiotic cocktail administration deplete ameliorated inflammation by SCCPs. In fecal microbiota transplantation (FMT) assays, mice that received transplanted from SCCP-treated showed increased elevated inflammatory response. addition, exposure promotes zonulin expression tight junction injury, antibiotic inhibited intestinal tract. Increased injury were also observed SCCPs_FMT mice. The inhibition protected tract suppressed activation. summary, this study proposes a possibility for neurotoxicity microbiome-mediated junction.